Wagner A D, Schacter D L, Rotte M, Koutstaal W, Maril A, Dale A M, Rosen B R, Buckner R L
Massachusetts General Hospital NMR Center, Harvard Medical School, Charlestown, MA 02129, USA.
Science. 1998 Aug 21;281(5380):1188-91. doi: 10.1126/science.281.5380.1188.
A fundamental question about human memory is why some experiences are remembered whereas others are forgotten. Brain activation during word encoding was measured using blocked and event-related functional magnetic resonance imaging to examine how neural activation differs for subsequently remembered and subsequently forgotten experiences. Results revealed that the ability to later remember a verbal experience is predicted by the magnitude of activation in left prefrontal and temporal cortices during that experience. These findings provide direct evidence that left prefrontal and temporal regions jointly promote memory formation for verbalizable events.
关于人类记忆的一个基本问题是，为什么有些经历能被记住而有些却被遗忘。使用组块设计和事件相关功能磁共振成像来测量单词编码过程中的大脑激活，以研究随后被记住和随后被遗忘的经历在神经激活方面有何不同。结果显示，随后记住一段言语经历的能力可由该经历期间左前额叶和颞叶皮质的激活强度来预测。这些发现提供了直接证据，表明左前额叶和颞叶区域共同促进可言语化事件的记忆形成。
