Ruiz-Torres A, Kürten I, Rosenstock M
Beitr Pathol. 1976 Aug;158(3):287-95. doi: 10.1016/s0005-8165(76)80119-9.
The rates of synthesis and catabolism of collagen are determined in the livers of normal rats and of rats treated with carbon tetrachloride. Several experimental conditions are applied with the intention of investigating the dynamic processes separately, in order to determine the relevant values. The deposition of collagen in liver after damage by CCl4 is a consequence of the reduction of turnover with a simultaneous increase in collagen-production. Together with the increase in synthesis, which seems to be a consequence of a numerical increase in cells, there is a reduction in catabolism of collagen: the more severe the damage, the more marked is the decrease of specific catabolism. Collagen-deposition in the liver is thus the result of accumulation. The results indicate the possibility that collagen-catabolism is effected by enzymes produced by adjacent parenchymal cells, so that their destruction enhances the accumulation of collagen material. The findings mentioned above are discussed in the context of the general criteria of scar-formation and the repair of damaged tissues.
在正常大鼠和用四氯化碳处理过的大鼠肝脏中测定胶原蛋白的合成和分解代谢速率。应用了几种实验条件，旨在分别研究动态过程，以确定相关数值。四氯化碳损伤后肝脏中胶原蛋白的沉积是周转率降低同时胶原蛋白生成增加的结果。随着合成的增加（这似乎是细胞数量增加的结果），胶原蛋白的分解代谢减少：损伤越严重，特异性分解代谢的降低就越明显。因此，肝脏中胶原蛋白的沉积是积累的结果。结果表明，胶原蛋白分解代谢可能受相邻实质细胞产生的酶的影响，因此它们的破坏会增强胶原蛋白物质的积累。上述研究结果在瘢痕形成和受损组织修复的一般标准背景下进行了讨论。
