运动敏感度受损作为青光眼可疑患者后续视野缺损的预测指标：罗斯康芒青光眼研究
Impaired motion sensitivity as a predictor of subsequent field loss in glaucoma suspects: the Roscommon Glaucoma Study.
作者信息
Wu J, Coffey M, Reidy A, Wormald R
机构信息
Southampton University, Ophthalmic Epidemiology Unit.
出版信息
Br J Ophthalmol. 1998 May;82(5):534-7. doi: 10.1136/bjo.82.5.534.
AIM
To determine if impaired motion sensitivity is a significant predictor of subsequent field loss in glaucoma suspects.
METHOD
A population based prospective study; a 5 year follow up of all glaucoma suspects who had been identified from a population based random sample survey in the west of Ireland. 78 glaucoma suspects whose visual field function was annually measured by Henson CFS 2000 and for whom data on family history of glaucoma, ocular status, and motion impairment had been recorded. Visual field loss was defined as Henson visual field survival score of 94 or less.
RESULTS
18 people developed visual field loss in at least one eye. Motion impairment at baseline was associated with a 2-18 times greater risk of development of the visual field loss (p < 0.001). This association was independent of sex, family history of glaucoma, intraocular pressure, and C/D ratio at baseline. The Cox's proportional hazards regression analysis confirmed the above results after adjustment for age and the C/D ratio.
CONCLUSION
Motion impairment is an independent predictor of visual field loss in glaucoma suspects, although it is not clear how long motion impairment precedes visual field loss.
目的
确定运动敏感性受损是否是青光眼可疑患者后续视野缺损的重要预测指标。
方法
一项基于人群的前瞻性研究；对从爱尔兰西部基于人群的随机抽样调查中识别出的所有青光眼可疑患者进行为期5年的随访。78名青光眼可疑患者，其视野功能每年通过Henson CFS 2000测量，并记录了青光眼家族史、眼部状况和运动障碍的数据。视野缺损定义为Henson视野存活分数为94或更低。
结果
18人至少一只眼睛出现了视野缺损。基线时的运动障碍与视野缺损发生风险高2至18倍相关（p < 0.001）。这种关联独立于性别、青光眼家族史、眼压和基线时的杯盘比。Cox比例风险回归分析在调整年龄和杯盘比后证实了上述结果。
结论
运动障碍是青光眼可疑患者视野缺损的独立预测指标，尽管尚不清楚运动障碍在视野缺损之前出现多长时间。
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