Breton M E, Wilson T W, Wilson R, Spaeth G L, Krupin T
Scheie Eye Institute, Presbyterian-University of Pennsylvania Medical Center, Philadelphia 19104.
Invest Ophthalmol Vis Sci. 1991 Oct;32(11):2931-41.
The need for more sensitive tests for the early detection of compromised visual function in glaucoma is established by anatomic and psychophysical evidence of damage occurring to optic nerve fibers in eyes with normal visual fields. The results are reported of temporal frequency testing on 51 glaucoma suspects without visual field loss in either eye, 52 glaucoma patients with visual field deficits in the tested eye, and 11 normal subjects. Modulation transfer functions were obtained using a sinusoidally flickering 5 degrees spatially uniform white field viewed with central fixation and plotted at six frequencies from 5-30 Hz. The results showed a frequency-specific sensitivity loss centered at 15 Hz and a nonfrequency-specific mean sensitivity loss, that was greater, on average, in glaucoma patients than in suspects. Sensitivity losses of both kinds were seen in most glaucoma patients, but only in a minority of glaucoma suspects. About 12% of suspects were indistinguishable from the lowest performing one third of these glaucoma patients. A smaller number of suspects appeared to form a second mode in the frequency distribution for temporal sensitivity at 15 and 25 Hz. In patients with glaucoma, age was found to be a significant factor associated with the magnitude of mean sensitivity loss. Age was not a significant factor contributing to sensitivity loss in individual suspect data as measured by regression analysis, but it contributed to a small and consistent sensitivity loss across frequency for group-averaged data in those older than 55 years of age.
正常视野眼中视神经纤维受损的解剖学和心理物理学证据表明，需要更灵敏的测试来早期检测青光眼患者视觉功能的损害。报告了对51名双眼均无视野缺损的青光眼疑似患者、52名受试眼有视野缺损的青光眼患者以及11名正常受试者进行的时间频率测试结果。使用中央注视下可见的5度空间均匀的正弦闪烁白场获得调制传递函数，并在5至30赫兹的六个频率下绘制。结果显示，以15赫兹为中心存在频率特异性敏感性损失，以及非频率特异性平均敏感性损失，平均而言，青光眼患者的这种损失比疑似患者更大。大多数青光眼患者都出现了这两种敏感性损失，但只有少数青光眼疑似患者出现这种情况。约12%的疑似患者与这些青光眼患者中表现最差的三分之一无法区分。在15赫兹和25赫兹的时间敏感性频率分布中，有少数疑似患者似乎形成了第二种模式。在青光眼患者中发现，年龄是与平均敏感性损失程度相关的一个重要因素。通过回归分析测量，年龄在个体疑似患者数据中并非导致敏感性损失的重要因素，但对于55岁以上人群的组平均数据，年龄导致了整个频率范围内小而持续的敏感性损失。
