Sponsel W E, Ritch R, Stamper R, Higginbotham E J, Anderson D R, Wilson M R, Zimmerman T J
University of Texas Health Science Center, San Antonio, USA.
Am J Ophthalmol. 1995 Dec;120(6):699-708. doi: 10.1016/s0002-9394(14)72723-0.
To assess the screening efficacy and practical use of two portable devices to detect moderate to severe visual field loss rapidly in population screening.
Henson visual field analysis and Damato campimetry for glaucoma were performed in a healthy adult population, to determine false-positive rates; in established glaucoma patients and suspects, to determine false-negative rates; and in a general adult population, to assess practical use in actual screenings.
There were no false-positive test failures among the 82 normal subjects who completed the Henson two-step screening. Eighty of 83 normal subjects passed Damato campimetry, resulting in a false-positive rate of 3.6%. Among 83 glaucoma suspects and patients, the Henson test identified 49 (84%) of 58 subjects whose full-threshold fields from Humphrey perimetry were abnormal, 38 (97%) of 39 of whom had moderate to severe visual field loss. The Damato campimeter detected 55 (81%) of 68 subjects with any pathologic loss on full-threshold visual fields, 44 (92%) of 48 of whom had moderate to severe visual field loss. Among 1,278 subjects tested in general population screenings, 55 subjects (4.3%) failed either or both tests.
The Henson visual field analyzer can discriminate moderately to severely diseased from normal visual fields with high sensitivity and specificity. The Damato campimeter can reliably detect moderate to severe visual field loss with a tolerably low false-positive rate. To overcome the weakness of glaucoma screening by tonometry alone, some forms of visual field testing may be acceptably brief (cost effective) and accurate (sensitive and specific).
评估两种便携式设备在人群筛查中快速检测中度至重度视野缺损的筛查效果及实际应用价值。
对健康成年人群进行用于青光眼筛查的亨森视野分析和达马托平面视野计检查,以确定假阳性率;对确诊的青光眼患者和疑似患者进行检查,以确定假阴性率;并在普通成年人群中进行检查,以评估其在实际筛查中的实际应用价值。
完成亨森两步筛查的82名正常受试者中未出现假阳性检测失败情况。83名正常受试者中有80名通过了达马托平面视野计检查,假阳性率为3.6%。在83名青光眼疑似患者和患者中,亨森检查从58名 Humphrey 视野计全阈值视野异常的受试者中识别出49名(84%),其中39名中的38名(97%)有中度至重度视野缺损。达马托平面视野计在68名全阈值视野有任何病理性缺损的受试者中检测出55名(81%),其中48名中的44名(92%)有中度至重度视野缺损。在普通人群筛查中接受检查的1278名受试者中,55名受试者(4.3%)一项或两项检查未通过。
亨森视野分析仪能够以高灵敏度和特异性从中度至重度病变视野中区分出正常视野。达马托平面视野计能够可靠地检测中度至重度视野缺损,假阳性率可接受地低。为克服仅通过眼压测量进行青光眼筛查的不足,某些形式的视野检测可能在可接受的简短程度(成本效益高)和准确性(灵敏且特异)方面表现良好。