耐辐射球菌中DNA聚合酶pol基因不存在链特异性修复。

The absence of strand-specific repair for the DNA polymerase pol gene in Deinococcus radiodurans.

作者信息

Lin C S, Wang H C, Wong T Y, Liu J K

机构信息

Department of Marine Resources, National Sun Yat-sen University, Kaohsiung, Taiwan, ROC.

出版信息

Biochem Mol Biol Int. 1998 Jul;45(4):651-62. doi: 10.1080/15216549800203052.

DOI:10.1080/15216549800203052

PMID:9713687

Abstract

Deinococcus radiodurans is characterized by its extreme resistance to ionizing radiation. Although Mn+2 was taken up by the cells at a high speed, the absorption of Mn+2 by the cells did not affect their survival rate when irradiated by UV light. However, the Mn-induced-cell-division (Mn-CD) cells do lose their resistance to UV radiation. This can be explained by the fact that the Mn-CD cells were less efficient to remove pyrimidine dimers on damaged DNA. We also found that there is no strand-specific repair of the pol gene in this organism.

摘要

耐辐射球菌的特点是对电离辐射具有极强的抗性。虽然Mn²⁺能被细胞快速摄取，但细胞对Mn²⁺的吸收并不影响其在紫外线照射下的存活率。然而，锰诱导细胞分裂（Mn-CD）的细胞确实会失去对紫外线辐射的抗性。这可以通过Mn-CD细胞在修复受损DNA上的嘧啶二聚体时效率较低这一事实来解释。我们还发现，在这种生物体中，pol基因不存在链特异性修复。