Izumiya Y, Jang H K, Kashiwase H, Cai J S, Nishimura Y, Tsushima Y, Kato K, Miyazawa T, Kai C, Mikami T
Department of Veterinary Microbiology, Faculty of Agriculture, The University of Tokyo, Japan.
J Gen Virol. 1998 Aug;79 ( Pt 8):1997-2001. doi: 10.1099/0022-1317-79-8-1997.
Studies on Marek's disease virus serotype 2 (MDV2) are important for understanding the natural nonpathogenic phenotypes of MDV. We determined the 16770 bp nucleotide sequence of the MDV2 genome located in the right part the of unique long region. The analysis revealed 12 complete open reading frames (ORFs) with high amino acid sequence identities to the gene products of other alphaherpesviruses. The MDV2 ORFs were arranged collinearly with the prototype sequence of herpes simplex virus type 1 ranging from the UL41 to UL51 genes. Except for the MDV2 UL41 gene, all of the identified genes were confirmed to be transcribed with 3'-coterminal mRNAs and/or a unique transcript in the virus-infected cells. Transcriptional patterns for the regions of the MDV2 UL48 to UL49.5 genes were notably different from the similar area of MDV serotype 1.
对马立克氏病病毒2型（MDV2）的研究对于理解MDV的天然非致病表型很重要。我们确定了位于独特长区域右侧部分的MDV2基因组的16770 bp核苷酸序列。分析揭示了12个完整的开放阅读框（ORF），它们与其他α疱疹病毒的基因产物具有高度的氨基酸序列同一性。MDV2的ORF与单纯疱疹病毒1型从UL41到UL51基因的原型序列共线排列。除MDV2 UL41基因外，所有已鉴定的基因均被证实在病毒感染的细胞中以3'共末端mRNA和/或独特转录本进行转录。MDV2 UL48至UL49.5基因区域的转录模式与MDV1型的相似区域明显不同。
