Collins J J, Acquavella J F
Solutia, Inc, St Louis, Missouri 63166-6760, United States.
Scand J Work Environ Health. 1998;24 Suppl 2:71-80.
Twenty-five epidemiologic studies of acrylonitrile workers were reviewed and subjected to meta-analytic techniques in this study to assess the findings for 10 cancer sites. The analyses indicate that workers with acrylonitrile exposure have essentially null findings for most cancers, including lung [meta-relative risk (mRR) 0.9, 95% confidence interval (95% CI) 0.9-1.1], brain (mRR 1.2, 95% CI 0.8-1.7), and prostate (mRR 1.0, 95% CI 0.7-1.4) cancers. Bladder cancer rates were elevated (mRR 1.8, 95% CI 1.0-3.4), but the excess was not dose-related and was limited to plants with aromatic amines. Therefore, the bladder cancer excess is unlikely to be related to acrylonitrile exposure. Some evidence of publication bias was found in the examined literature, but the bias did not have a significant impact on risk estimates for individual cancers. It was concluded that the available studies do not support a causal relation between acrylonitrile exposure and cancer.
本研究回顾了25项关于丙烯腈工人的流行病学研究，并采用荟萃分析技术来评估10个癌症部位的研究结果。分析表明，接触丙烯腈的工人在大多数癌症方面基本无显著结果，包括肺癌[荟萃相对风险（mRR）为0.9，95%置信区间（95%CI）为0.9 - 1.1]、脑癌（mRR为1.2，95%CI为0.8 - 1.7）和前列腺癌（mRR为1.0，95%CI为0.7 - 1.4）。膀胱癌发病率有所升高（mRR为1.8，95%CI为1.0 - 3.4），但这种增加与剂量无关，且仅限于存在芳香胺的工厂。因此，膀胱癌发病率的增加不太可能与丙烯腈接触有关。在所审查的文献中发现了一些发表偏倚的证据，但这种偏倚对个别癌症的风险估计没有显著影响。研究得出结论，现有研究不支持丙烯腈接触与癌症之间存在因果关系。
