Benn T, Osborne K
Epidemiology and Medical Statistics Unit, Bootle, United Kingdom.
Scand J Work Environ Health. 1998;24 Suppl 2:17-24.
The mortality experience of 2763 men employed between 1950 and 1978 for at least 1 year at 6 factories involved in the polymerization of acrylonitrile and the spinning of acrylic fiber was followed to the end of 1991. Overall, cancer deaths did not exceed the expected numbers. There were, however, excess cancer deaths among the workers in the jobs more highly exposed to acrylonitrile. The excesses did not reach conventional levels of statistical significance apart from an excess of lung cancer among workers under 45 years of age. Detailed analyses provided no consistent support for a causal association between acrylonitrile exposure and carcinogenesis. The limitations of the study, including a lack of information on smoking habits and very limited estimates of acrylonitrile exposure, need to be borne in mind.
对1950年至1978年间在6家从事丙烯腈聚合和腈纶纺丝的工厂工作至少1年的2763名男性的死亡情况进行了跟踪，直至1991年底。总体而言，癌症死亡人数未超过预期。然而，在接触丙烯腈程度较高的工作岗位的工人中，癌症死亡人数有所增加。除了45岁以下工人中的肺癌死亡人数增加外，这些增加并未达到传统的统计学显著水平。详细分析并未一致支持丙烯腈接触与致癌作用之间存在因果关系。需要牢记该研究的局限性，包括缺乏吸烟习惯信息以及对丙烯腈接触的估计非常有限。
