Hibbeln J R, Umhau J C, Linnoila M, George D T, Ragan P W, Shoaf S E, Vaughan M R, Rawlings R, Salem N
Laboratory of Membrane Biochemistry and Biophysics, National Institute on Alcohol Abuse and Alcoholism, Bethesda, Maryland, USA.
Biol Psychiatry. 1998 Aug 15;44(4):243-9. doi: 10.1016/s0006-3223(98)00143-7.
Among an independent group of subjects selected for their history of violent, impulsive behaviors and nonviolent control subjects, we attempted to replicate the finding that plasma docosahexaenoic acid concentrations were negatively correlated with cerebrospinal fluid 5-hydroxyindoleacetic acid (CSF 5-HIAA) concentrations.
CSF 5-HIAA and homovanillic acid (HVA), fasting total cholesterol, and plasma fatty acid concentrations were examined in violent and nonviolent subjects matched for their severity of alcohol dependence.
Violent subjects had significantly higher lifetime violence and hostility ratings and lower concentrations of CSF 5-HIAA than nonviolent subjects. Plasma docosahexaenoic acid was negatively correlated with CSF 5-HIAA only among violent subjects.
This observational study suggests that dietary essential fatty acids may change neurotransmitter concentrations. Prospective dietary intervention trials will be required to determine if increasing dietary intake of docosahexaenoic acid will increase or decrease either CSF 5-HIAA concentrations or impulsive and violent behaviors.
在一组因暴力、冲动行为史而被挑选出的独立研究对象以及非暴力对照对象中，我们试图重现血浆二十二碳六烯酸浓度与脑脊液5-羟吲哚乙酸（CSF 5-HIAA）浓度呈负相关这一发现。
对酒精依赖严重程度相匹配的暴力和非暴力研究对象的脑脊液5-HIAA和高香草酸（HVA）、空腹总胆固醇以及血浆脂肪酸浓度进行检测。
暴力研究对象的终身暴力和敌意评分显著更高，且脑脊液5-HIAA浓度低于非暴力研究对象。仅在暴力研究对象中，血浆二十二碳六烯酸与脑脊液5-HIAA呈负相关。
这项观察性研究表明，膳食必需脂肪酸可能会改变神经递质浓度。需要进行前瞻性膳食干预试验，以确定增加二十二碳六烯酸的膳食摄入量是否会增加或降低脑脊液5-HIAA浓度或冲动及暴力行为。
