Gasbarrini A, Serricchio M, Tondi P, Franceschi F, Ojetti V, Pola R, Flore R, Santoliquido A, Gasbarrini G, Pola P
Angiology and Internal Medicine Department, Catholic University of Rome, Rome Italy
Int J Angiol. 1998 Aug;7(4):307-9. doi: 10.1007/s005479900120.
Raynaud's phenomenon is an intermittent vasospasm of the arterioles of the distal limbs which occurs mostly following exposure to cold or emotional stimuli. Helicobacter pylori infection, the most relevant cause of gastritis, has been associated with some vascular diseases. The aim of this study was to assess the prevalence of H. pylori infection and effects of eradication on Raynaud attacks. Twenty-five patients affected by primary Raynaud's phenomenon were evaluated. H. pylori infection was assessed by the 13C urea breath test and 20 subjects were found to be infected by the bacterium. Triple therapy consisting of amoxicillin, clarithromycin, and lansoprazole was given to the patients for 7 days at the time of diagnosis. Duration and frequency of clinical attacks of Raynaud's phenomenon per week were assessed for 12 weeks after eradication. In 80 percent of the patients Raynaud's was eradicated after therapy. Clinical attacks of Raynaud's phenomenon completely disappeared in 18% of the eradicated patients. Duration and frequency of attacks were significantly reduced in 68% of the remaining patients. The preliminary findings from this study show that H. pylori eradication significantly ameliorates primary Raynaud's disease.
雷诺现象是一种远端肢体小动脉的间歇性血管痉挛，大多在暴露于寒冷或情绪刺激后发生。幽门螺杆菌感染是胃炎最主要的相关病因，它与一些血管疾病有关。本研究的目的是评估幽门螺杆菌感染的患病率以及根除幽门螺杆菌对雷诺发作的影响。对25例原发性雷诺现象患者进行了评估。通过13C尿素呼气试验评估幽门螺杆菌感染情况，发现20例患者感染了该细菌。在诊断时，给予患者阿莫西林、克拉霉素和兰索拉唑组成的三联疗法，疗程7天。在根除幽门螺杆菌后12周，评估雷诺现象临床发作的持续时间和每周发作频率。80%的患者在治疗后雷诺现象得到根除。18%根除幽门螺杆菌的患者雷诺现象的临床发作完全消失。其余68%的患者发作的持续时间和频率显著降低。本研究的初步结果表明，根除幽门螺杆菌可显著改善原发性雷诺病。
