Ahmed I, Adeghate E, Sharma A K, Pallot D J, Singh J
Department of Human Anatomy, Faculty of Medicine and Health Sciences, United Arab Emirates University, Al Ain, United Arab Emirates.
Diabetes Res Clin Pract. 1998 Jun;40(3):145-51. doi: 10.1016/s0168-8227(98)00022-9.
An investigation was made of the effect of Momordica charantia fruit juice on the distribution and number of alpha, beta and delta cells in the pancreas of streptozotocin (STZ)-induced diabetic rats using immunohistochemical methods. The results indicated that there was a significant (Student's t-test, P < 0.004) increase in the number of beta cells in M. charantia-treated animals when compared with untreated diabetics, however, their number was still significantly less than that obtained for normal rats. There was also a significant (P < 0.006) increase in the number of delta cells in STZ-diabetic rats compared to non-diabetic rats. This increase in the number of delta cells was not affected by M. charantia treatment. The number of alpha cells did not change significantly in M. charantia-treated rats when compared with untreated diabetic rats. Our results suggest that oral feeding of M. charantia fruit juice may have a role in the renewal of beta cells in STZ-diabetic rats or alternately may permit the recovery of partially destroyed beta cells.
采用免疫组织化学方法，研究了苦瓜果汁对链脲佐菌素（STZ）诱导的糖尿病大鼠胰腺中α、β和δ细胞分布及数量的影响。结果表明，与未治疗的糖尿病大鼠相比，用苦瓜治疗的动物β细胞数量显著增加（学生t检验，P<0.004），然而，其数量仍显著低于正常大鼠。与非糖尿病大鼠相比，STZ糖尿病大鼠的δ细胞数量也显著增加（P<0.006）。δ细胞数量的这种增加不受苦瓜治疗的影响。与未治疗的糖尿病大鼠相比，用苦瓜治疗的大鼠α细胞数量没有显著变化。我们的结果表明，口服苦瓜果汁可能对STZ糖尿病大鼠β细胞的更新有作用，或者可能使部分受损的β细胞恢复。
