Sathishsekar Dhanasekar, Subramanian Sorimuthu
Department of Biochemistry and Molecular Biology, University of Madras, Chennai, India.
Biol Pharm Bull. 2005 Jun;28(6):978-83. doi: 10.1248/bpb.28.978.
The aim of the present study was to evaluate the effect of the aqueous extract of seeds of two varieties, namely a country and hybrid variety of Momordica charantia (MCSEt1 and MCSEt2) on oxidative stress in plasma and pancreas of streptozotocin (STZ) induced diabetic rats. Oral administration of each of the seed extracts at a dosage of 150 mg/kg body weight for 30 d resulted in a significant reduction in plasma glucose, thiobarbituric acid-reactive substances, lipid-hydroperoxides, alpha-tocopherol and significant improvement in ascorbic acid, reduced glutathione and insulin. The treatment also resulted in a significant reduction in thiobarbituric acid reactive substances, lipid-hydroperoxides, superoxide dismutase, catalase, glutathione peroxidase and significant improvement in reduced glutathione in pancreas of drug treated diabetic rats when compared to the untreated diabetic rats. On the basis of results obtained, it may be concluded that the treatment of Momordica charantia seed varieties may effectively normalize the impaired oxidative stress in streptozotocin induced-diabetes than the glibenclamide treated groups.
本研究的目的是评估两种品种（即国产苦瓜品种和杂交苦瓜品种）的种子水提取物（MCSEt1和MCSEt2）对链脲佐菌素（STZ）诱导的糖尿病大鼠血浆和胰腺氧化应激的影响。以150 mg/kg体重的剂量口服给予每种种子提取物，持续30天，结果显示血浆葡萄糖、硫代巴比妥酸反应性物质、脂质氢过氧化物、α-生育酚显著降低，而抗坏血酸、还原型谷胱甘肽和胰岛素显著改善。与未治疗的糖尿病大鼠相比，该治疗还导致药物治疗的糖尿病大鼠胰腺中硫代巴比妥酸反应性物质、脂质氢过氧化物、超氧化物歧化酶、过氧化氢酶、谷胱甘肽过氧化物酶显著降低，还原型谷胱甘肽显著改善。根据所得结果，可以得出结论，与格列本脲治疗组相比，苦瓜种子品种的治疗可能更有效地使链脲佐菌素诱导的糖尿病中受损的氧化应激恢复正常。
