Kashden J, Frison S, Fowler K, Pass R F, Boll T J
Department of Psychology, Healthsouth Mountainview Regional Rehabilitation Hospital, Morgantown, West Virginia 26505, USA.
J Dev Behav Pediatr. 1998 Aug;19(4):254-9. doi: 10.1097/00004703-199808000-00003.
The findings of previous studies examining the neurocognitive development of children with clinically inapparent (asymptomatic) cytomegalovirus (CMV) infection have demonstrated mixed results. These studies have generally depended on small sample sizes (i.e., < 50). We examined the intellectual development of children with asymptomatic congenital CMV infection using a sample larger than previous studies. Two hundred and four cases aged 5 to 200 months were compared with 177 uninfected siblings ranging in age from 6 to 203 months. Parents were administered the Developmental Profile, a measure of developmental achievement. Children who were older than 30 months were administered an objective intelligence measure. Results of this study showed that children with asymptomatic congenital CMV infection do not demonstrate intellectual impairment, and that they perform similarly to uninfected siblings. Parents tended to overestimate their child's level of functioning regardless of whether the child had CMV infection.
以往研究针对临床无明显症状（无症状）的巨细胞病毒（CMV）感染儿童的神经认知发育情况，结果不一。这些研究通常样本量较小（即<50）。我们使用了比以往研究更大的样本，来研究无症状先天性CMV感染儿童的智力发育情况。将204例年龄在5至200个月的患儿与177名年龄在6至203个月的未感染同胞进行比较。对家长进行了发育概况测试，这是一种衡量发育成就的方法。对年龄超过30个月的儿童进行了客观智力测试。这项研究的结果表明，无症状先天性CMV感染儿童没有智力障碍，其表现与未感染的同胞相似。无论孩子是否感染CMV，家长往往都会高估其孩子的功能水平。
