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Synthesis of eel-calcitonin and (asu1,7)-eel-calcitonin: contribution of the disulfide bond to the hormonal activity.

作者信息

Morikawa T, Munekata E, Sakakibara S, Noda T, Otani M

出版信息

Experientia. 1976 Sep 15;32(9):1104-6. doi: 10.1007/BF01927568.

DOI:10.1007/BF01927568
PMID:971732
Abstract

Eel-calcitonin and its [asu1,7]-analog, deamino-dicarba-analog, were synthesized by the conventional solution method. The natural-type product showed 4300 MRC U/mg in the hypocalcemic potency which was comparable to that of the natural hormone isolated from eel. Hormonal activity of the Asu-analog was also as high as 3400 MRC U/mg.

摘要

相似文献

1
Synthesis of eel-calcitonin and (asu1,7)-eel-calcitonin: contribution of the disulfide bond to the hormonal activity.
Experientia. 1976 Sep 15;32(9):1104-6. doi: 10.1007/BF01927568.
2
[Asu(1,7)E-CT, an analog of eel calcitonin. A comparative study in man with reference to other synthetic calcitonins].[鳗降钙素类似物Asu(1,7)E-CT。与其他合成降钙素相比的人体对照研究]
Minerva Med. 1983 Apr 28;74(18):993-1010.
3
Stability of [Asu1,7]-eel calcitonin and eel calcitonin in vitro and in vivo.[天冬酰胺1,7]-鳗鱼降钙素和鳗鱼降钙素在体内外的稳定性
Endocrinol Jpn. 1977 Jun;24(3):281-5. doi: 10.1507/endocrj1954.24.281.
4
Comparative effects of eel calcitonin, salmon calcitonin and [Asu1,7]eel calcitonin on hypophyseal and osteoblastic function.鳗鱼降钙素、鲑鱼降钙素和[Asu1,7]鳗鱼降钙素对垂体和成骨细胞功能的比较作用。
Gynecol Endocrinol. 1993 Jun;7(2):89-96. doi: 10.3109/09513599309152486.
5
Bimodal action of [Asu1,7]eel-calcitonin on phosphoinositide hydrolysis in cultured anterior pituitary cells.[Asu1,7]鳗鱼降钙素对培养的垂体前叶细胞中磷酸肌醇水解的双峰作用。
Eur J Pharmacol. 1991 Aug 14;207(4):345-50. doi: 10.1016/0922-4106(91)90009-7.
6
Eel calcitonin suppresses plasma human calcitonin levels in medullary carcinoma of the thyroid.鳗鱼降钙素可抑制甲状腺髓样癌患者血浆中人类降钙素水平。
Clin Sci (Lond). 1986 Apr;70(4):333-8. doi: 10.1042/cs0700333.
7
Adenylate cyclase activation and competitive binding with renal tissue using synthetic eel calcitonin analog and its fragments.
Endocrinology. 1981 Feb;108(2):698-702. doi: 10.1210/endo-108-2-698.
8
[Profile of a new calcitonin: carbocalcitonin-(Asu1,7) E-CT].
Minerva Med. 1984 Jul 31;75(30-31):1809-18.
9
Effects of bovine parathyroid extract and [Asu1,7]-eel calcitonin on 35S incorporation into chick embryonic cartilage.牛甲状旁腺提取物和[Asu1,7]-鳗鱼降钙素对35S掺入鸡胚软骨的影响。
Endocrinol Jpn. 1982 Aug;29(4):479-82. doi: 10.1507/endocrj1954.29.479.
10
International Standards for salmon calcitonin, eel calcitonin, and the Asu1-7 analogue of eel calcitonin: calibration by international collaborative study.鲑鱼降钙素、鳗鱼降钙素及鳗鱼降钙素Asu1-7类似物的国际标准：通过国际协作研究进行校准
Bone Miner. 1990 Oct;11(1):1-17. doi: 10.1016/0169-6009(90)90011-4.

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Mol Metab. 2021 Apr;46:101109. doi: 10.1016/j.molmet.2020.101109. Epub 2020 Nov 7.
2
Calcitonin and Bone Physiology: In Vitro, In Vivo, and Clinical Investigations.降钙素与骨生理学：体外、体内及临床研究
Int J Endocrinol. 2020 Sep 10;2020:3236828. doi: 10.1155/2020/3236828. eCollection 2020.
3
Efficacy and safety of elcatonin in postmenopausal women with osteoporosis: a systematic review with network meta-analysis of randomized clinical trials.

本文引用的文献

1
A biological assay for calcitonin.
J Endocrinol. 1965 Nov;33(3):469-75. doi: 10.1677/joe.0.0330469.
2
A new method for releasing oxytocin from fully-protected nona-peptides using anhydrous hydrogen fluoride.一种使用无水氟化氢从完全保护的九肽中释放催产素的新方法。
Bull Chem Soc Jpn. 1965 Aug;38(8):1412-3. doi: 10.1246/bcsj.38.1412.
3
Amino acid composition of salmon calcitonin.
Can J Biochem. 1969 Aug;47(8):823-5. doi: 10.1139/o69-128.
4
依降钙素治疗绝经后骨质疏松症女性的疗效和安全性：一项随机临床试验的系统评价和网络荟萃分析。
Osteoporos Int. 2019 Sep;30(9):1723-1732. doi: 10.1007/s00198-019-04997-6. Epub 2019 May 1.
4
Effectiveness of elcatonin for alleviating pain and inhibiting bone resorption in patients with osteoporotic vertebral fractures.依降钙素对骨质疏松性椎体骨折患者缓解疼痛及抑制骨吸收的有效性。
J Bone Miner Metab. 2017 Sep;35(5):544-553. doi: 10.1007/s00774-016-0791-6. Epub 2016 Nov 9.
5
Improvement of Quality of Life (QOL) in Osteoporotic Patients by Elcatonin Treatment: A Trial Taking the Participants' Preference into Account.依降钙素治疗对骨质疏松症患者生活质量的改善：一项考虑参与者偏好的试验
Jpn Clin Med. 2012 Apr 18;3:9-14. doi: 10.4137/JCM.S8291. eCollection 2012.
6
Accelerators of osteogenesis by recombinant human bone morphogenetic protein-2.重组人骨形态发生蛋白-2对成骨的促进作用
Drug Target Insights. 2007;2:55-60. Epub 2007 Feb 21.
7
Alendronate is more effective than elcatonin in improving pain and quality of life in postmenopausal women with osteoporosis.阿仑膦酸钠比依降钙素更能有效改善绝经后骨质疏松症妇女的疼痛和生活质量。
Osteoporos Int. 2011 Oct;22(10):2735-42. doi: 10.1007/s00198-010-1495-8. Epub 2010 Nov 23.
8
Effects of short-term combined treatment with alendronate and elcatonin on bone mineral density and bone turnover in postmenopausal women with osteoporosis.阿仑膦酸钠与依降钙素短期联合治疗对绝经后骨质疏松症患者骨密度和骨转换的影响。
Ther Clin Risk Manag. 2009 Jun;5(3):499-505. doi: 10.2147/tcrm.s5982. Epub 2009 Jul 12.
9
Effects of combined elcatonin and alendronate treatment on the architecture and strength of bone in ovariectomized rats.联合使用依降钙素和阿仑膦酸钠治疗对去卵巢大鼠骨骼结构和强度的影响。
J Bone Miner Metab. 2005;23(5):351-8. doi: 10.1007/s00774-005-0612-9.
10
Folding analysis of hormonal polypeptide calcitonins and the oxidized calcitonins using electrospray ionization mass spectrometry combined with H/D exchange.使用电喷雾电离质谱联用氢/氘交换技术对激素多肽降钙素及氧化降钙素进行折叠分析。
J Am Soc Mass Spectrom. 2004 Nov;15(11):1556-64. doi: 10.1016/j.jasms.2004.07.007.
Isolation and chemical properties of two calcitonins from salmon ultimobranchial glands.
从鲑鱼后鳃腺中分离出两种降钙素及其化学性质
J Biol Chem. 1970 Mar 25;245(6):1491-6.
5
[Synthesis of salmon calcitonin, a high activity hypocalcemic hormone].
Helv Chim Acta. 1969;52(7):1789-95. doi: 10.1002/hlca.19690520702.
6
Amino acid sequence of salmon ultimobranchial calcitonin.鲑鱼鳃后体降钙素的氨基酸序列。
Proc Natl Acad Sci U S A. 1969 Oct;64(2):771-8. doi: 10.1073/pnas.64.2.771.
7
[Structure-activity relationship of human calcitonin. III. Biological activity of synthetic analogues with shortened or terminally modified peptide chains (author's transl)].人降钙素的构效关系。III. 肽链缩短或末端修饰的合成类似物的生物活性（作者译）
Experientia. 1976 Feb 15;32(2):246-8. doi: 10.1007/BF01937791.