Synthesis of eel-calcitonin and (asu1,7)-eel-calcitonin: contribution of the disulfide bond to the hormonal activity.
作者信息
Morikawa T, Munekata E, Sakakibara S, Noda T, Otani M
出版信息
Experientia. 1976 Sep 15;32(9):1104-6. doi: 10.1007/BF01927568.
PMID:971732
Abstract
Eel-calcitonin and its [asu1,7]-analog, deamino-dicarba-analog, were synthesized by the conventional solution method. The natural-type product showed 4300 MRC U/mg in the hypocalcemic potency which was comparable to that of the natural hormone isolated from eel. Hormonal activity of the Asu-analog was also as high as 3400 MRC U/mg.
摘要
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