Rautoma P, Svartling N
Department of Anaesthesia, Töölö Hospital, University of Helsinki, Finland.
Can J Anaesth. 1998 Jul;45(7):651-4. doi: 10.1007/BF03012095.
To compare the potency of rocuronium in non-smokers and smokers during general anaesthesia.
In a randomized, open clinical study, 40 patients, 17-62 yr of age, were anaesthetized with propofol, alfentanil and nitrous oxide in oxygen. After obtaining individual dose-response curves for rocuronium, bolus doses of rocuronium were given to maintain neuromuscular block at 90-99% for 60 min. Evoked adductor pollicis electromyography (EMG) was used to monitor neuromuscular block.
The ED95 values (+/- SEM) for rocuronium were 460.5 +/- 28.9 and 471.5 +/- 22.1 micrograms.kg-1 for non-smokers and smokers, respectively (P:NS). However, doses of rocuronium to maintain 90-99% neuromuscular block (+/- SEM) were 620.1 +/- 46.7 and 747.4 +/- 56.0 micrograms.kg-1.hr-1 for non-smokers and smokers, respectively (P = 0.0504).
The results may indicate increased metabolism of rocuronium in smokers rather than increased requirement of rocuronium at the receptor site.
比较全身麻醉期间非吸烟者和吸烟者中罗库溴铵的效能。
在一项随机、开放的临床研究中，40名年龄在17至62岁之间的患者接受了丙泊酚、阿芬太尼和氧化亚氮与氧气混合的麻醉。在获得罗库溴铵的个体剂量-反应曲线后，给予罗库溴铵推注剂量以维持神经肌肉阻滞在90%-99%达60分钟。采用拇内收肌诱发肌电图（EMG）监测神经肌肉阻滞。
罗库溴铵的ED95值（±标准误）在非吸烟者和吸烟者中分别为460.5±28.9和471.5±22.1微克·千克-1（P：无显著性差异）。然而，维持90%-99%神经肌肉阻滞（±标准误）的罗库溴铵剂量在非吸烟者和吸烟者中分别为620.1±46.7和747.4±56.0微克·千克-1·小时-1（P = 0.0504）。
结果可能表明吸烟者中罗库溴铵的代谢增加，而非受体部位对罗库溴铵的需求增加。
