Is placebo analgesia mediated by endogenous opioids? A systematic review.

作者信息

Ter Riet Gerben, de Craen Anton J M, de Boer Anthonius, Kessels Alphons G H

机构信息

Department of Epidemiology, Maastricht University, P.O. Box 616, 6200 MD Maastricht, The Netherlands Department of Clinical Epidemiology and Biostatistics, Academic Medical Center, University of Amsterdam, P.O. Box 22700, 1100 DE Amsterdam, The Netherlands Department of Pharmacoepidemiology and Pharmacotherapy, Utrecht Institute of Pharmaceutical Sciences (UIPS), P.O. Box 80082, 3508 TB Utrecht, The Netherlands.

出版信息

Pain. 1998 Jun;76(3):273-275. doi: 10.1016/S0304-3959(98)00057-8.

DOI:10.1016/S0304-3959(98)00057-8

PMID:9718245

Abstract

This systematic review assesses six experimental studies into the mechanism of placebo analgesia in human subjects suffering from clinical pain or experimentally induced ischaemic arm pain. Due to their sophisticated designs, these studies probably provide the best evidence that placebo analgesia exists. They also indicate that placebo analgesia is mediated by endogenous opiates. However, there seems to be room for additional studies.

摘要