Fischer H, Andersson J L, Furmark T, Fredrikson M
Department of Psychology, Uppsala University, Sweden.
Neurosci Lett. 1998 Jul 24;251(2):137-40. doi: 10.1016/s0304-3940(98)00503-5.
Previous brain imaging studies on symptom provocation in panic anxiety have used either drug-infusions or sensory related stimulation to induce panic attacks. We here report positron emission tomographic measurements of regional cerebral blood flow (rCBF) during an unexpected panic attack in a healthy female volunteer participating in a fear conditioning study. During a first but not a second run with electric shock presentations the woman unexpectedly experienced a panic attack that fulfilled the DSM-IV criteria. Panic was associated with decreased rCBF in the right orbitofrontal (Brodmann area 11), prelimbic (area 25), anterior cingulate (area 32) and anterior temporal cortices (area 15). These findings suggest that neural activity in brain regions previously associated with symptom provocation in specific phobics and subjects with posttraumatic stress disorder also are involved during panic in healthy individuals.
先前关于惊恐焦虑症状激发的脑成像研究，要么使用药物输注，要么使用与感觉相关的刺激来诱发惊恐发作。我们在此报告了一名参与恐惧条件反射研究的健康女性志愿者在意外惊恐发作期间的正电子发射断层扫描区域脑血流（rCBF）测量结果。在第一次但不是第二次电击呈现过程中，该女性意外经历了一次符合DSM-IV标准的惊恐发作。惊恐与右侧眶额（布罗德曼区11）、前边缘（区25）、前扣带回（区32）和颞叶前部皮质（区15）的rCBF降低有关。这些发现表明，先前与特定恐惧症和创伤后应激障碍患者症状激发相关的脑区神经活动，在健康个体的惊恐发作期间也会涉及。
