Reiman E M, Raichle M E, Robins E, Mintun M A, Fusselman M J, Fox P T, Price J L, Hackman K A
Department of Psychiatry, Mallinckrodt Institute of Radiology, St. Louis, MO 63110.
Arch Gen Psychiatry. 1989 Jun;46(6):493-500. doi: 10.1001/archpsyc.1989.01810060013003.
Positron emission tomographic measurements of regional blood flow were used to assess local neuronal activity in patients with panic disorder and in normal control subjects before and during the infusion of sodium lactate. A new technique for the analysis of positron emission tomographic data was employed to identify significant changes in regional blood flow associated with lactate infusion in the panicking patients, nonpanicking patients, and controls. Lactate-induced panic was associated with significant blood flow increases bilaterally in the temporal poles; bilaterally in insular cortex, claustrum, or lateral putamen; bilaterally in or near the superior colliculus; and in or near the left anterior cerebellar vermis. Lactate infusion was not associated with significant changes in regional blood flow in the nonpanicking patients or control subjects. Thus, the identified regions seemed to be involved in an anxiety attack.
利用正电子发射断层扫描测量局部脑血流，以评估惊恐障碍患者和正常对照受试者在输注乳酸钠之前及期间的局部神经元活动。采用一种分析正电子发射断层扫描数据的新技术，来确定惊恐患者、非惊恐患者和对照受试者中与输注乳酸相关的局部脑血流的显著变化。乳酸诱发的惊恐与双侧颞极、双侧岛叶皮质、屏状核或外侧壳核、双侧上丘或其附近、以及左侧小脑蚓部或其附近的显著血流增加有关。在非惊恐患者或对照受试者中，输注乳酸与局部脑血流的显著变化无关。因此，所确定的区域似乎与焦虑发作有关。
