Horisberger J D
Institute of Pharmacology and Toxicology, Lausanne, Switzerland.
Curr Opin Cell Biol. 1998 Aug;10(4):443-9. doi: 10.1016/s0955-0674(98)80056-2.
The emerging epithelial Na channel/degenerin family of sodium channels is rapidly expanding, in particular with new members expressed in mammalian neurons and potentially involved in pain transmission. Experimental evidence supports a four-subunit stoichiometry for these channels (although this is still controversial), and basic functional elements (pore and selectivity filter, amiloride binding site, gating) have started to be attributed to specific domains of the protein. Although much remains to be done, in the past year progress has been made in the understanding of several regulatory mechanisms: the control of epithelial Na channel translation by mineralocorticoid hormones, the role of endocytosis and ubiquitination for degradation in the control of the channel density and the role of extracellular proteases.
新兴的上皮钠通道/退化素钠通道家族正在迅速扩展，特别是在哺乳动物神经元中表达的新成员，可能参与疼痛传递。实验证据支持这些通道的四亚基化学计量比（尽管这仍存在争议），并且基本功能元件（孔道和选择性过滤器、氨氯地平结合位点、门控）已开始归因于蛋白质的特定结构域。尽管仍有许多工作要做，但在过去一年中，在理解几种调节机制方面取得了进展：盐皮质激素对上皮钠通道翻译的控制、内吞作用和泛素化在通道密度控制中的降解作用以及细胞外蛋白酶的作用。
