Krongrad A, Litwin M S, Lai H, Lai S
Department of Urology, University of Miami School of Medicine, VA Medical Center, Florida 33125, USA.
J Urol. 1998 Sep;160(3 Pt 1):807-10. doi: 10.1016/S0022-5347(01)62792-7.
Quality of life research in prostate cancer involves the use of many questionnaires and specific items that may be partly redundant. We examine dimensions of quality of life in prostate cancer in the hope of somewhat simplifying communication of basic information.
We analyzed cross-sectional survey data on quality of life in patients with prostate cancer belonging to a Southern California HMO. Quality of life was assessed with the University of California, Los Angeles prostate cancer index. Scree plot and parallel analysis were used to identify factors for extraction and orthogonal (varimax) rotation to examine scale loadings.
Four extracted factors explained a cumulative variance of 86%. The 8 physical and emotional scales loaded on 1 general factor explained 41% of the cumulative variance. Urinary function and bother, sexual function and bother, and bowel function and bother scales loaded on factors explained 16, 15 and 14% of the cumulative variance, respectively.
The observation of only 1 general quality of life factor diverges from consistent previous observations of distinct physical and emotional factors in other types of patients, and the tight interaction of emotional and physical scales supports the vulnerability hypothesis, "with age the increasing interactions across dimensions of health leave a patient vulnerable in all when any is affected." The tight interaction of physical and emotional scales in these but not other patients opens the door theoretically to better evaluation of and targeting of health services for patients with prostate cancer.
前列腺癌的生活质量研究涉及使用许多问卷和特定项目，这些可能部分存在冗余。我们研究前列腺癌生活质量的维度，希望能在一定程度上简化基本信息的交流。
我们分析了南加州健康维护组织（HMO）中前列腺癌患者生活质量的横断面调查数据。生活质量通过加利福尼亚大学洛杉矶分校前列腺癌指数进行评估。使用碎石图和平行分析来确定提取因子，并进行正交（方差最大化）旋转以检查量表负荷。
提取的四个因子解释了86%的累积方差。8个身体和情感量表加载在1个一般因子上，解释了41%的累积方差。排尿功能与困扰、性功能与困扰以及肠道功能与困扰量表加载在各因子上，分别解释了16%、15%和14%的累积方差。
仅观察到1个一般生活质量因子，这与之前在其他类型患者中一致观察到的不同身体和情感因子有所不同，并且身体和情感量表的紧密相互作用支持了脆弱性假说，即“随着年龄增长，健康各维度之间的相互作用增加，当任何一个维度受到影响时，患者在所有维度上都变得脆弱”。这些患者而非其他患者中身体和情感量表的紧密相互作用，从理论上为更好地评估前列腺癌患者的健康服务并将其作为目标提供了可能。
