Denn M J, Stone H L
J Appl Physiol. 1976 Jul;41(1):30-5. doi: 10.1152/jappl.1976.41.1.30.
The autonomic innervation of canine coronary arteries has been examined using the Falck and Owman technique for demonstrating catecholamines and a modification of the Koelle technique for the demonstration of cholinesterase. The experimental protocol included an examination of the neural innervation of the major coronary arteries: LCC, LAD, and RCA. A consistent, relatively dense adrenergic innervation was noted. A gradient in the degree of cholinergic innervation was: LAD less than RCA less than LCC. Light microscopic examination of the hearts of dogs subjected to either cervical vagotomy or total extrinsic cardiac denervation was performed. Additional surgical procedures included removal of the left stellate ganglion and a preferential stripping of the LCC. These studies demonstrated the intrinsic nature of parasympathetic coronary innervation. Following all surgical procedure no variations in density of cholinergic innervation were noted, indicating that these fibers are probably postganglionic parasympathetic fibers arising from intrinsic ganglia within the ventricles. These ganglia may be located at the base of the great vessels and send their fibers to the coronary vessels via the septal artery.
已采用法尔克和奥曼技术（用于显示儿茶酚胺）以及对科埃尔技术的一种改良方法（用于显示胆碱酯酶）对犬冠状动脉的自主神经支配进行了研究。实验方案包括对主要冠状动脉（左冠状动脉回旋支、左冠状动脉前降支和右冠状动脉）的神经支配进行检查。观察到一致且相对密集的肾上腺素能神经支配。胆碱能神经支配程度的梯度为：左冠状动脉前降支小于右冠状动脉小于左冠状动脉回旋支。对接受颈部迷走神经切断术或完全心脏外神经去支配术的犬心脏进行了光镜检查。额外的外科手术包括切除左侧星状神经节以及对左冠状动脉回旋支进行选择性剥离。这些研究证明了冠状动脉副交感神经支配的内在性质。在所有外科手术后，未观察到胆碱能神经支配密度的变化，表明这些纤维可能是起源于心室内固有神经节的节后副交感纤维。这些神经节可能位于大血管基部，并通过间隔动脉将其纤维发送至冠状动脉。
