Monfouilloux S, Avet-Loiseau H, Amarger V, Balazs I, Pourcel C, Vergnaud G
Laboratoire de Recherche en Génétique des Espèces, Institut de Biologie des Hôpitaux de Nantes, France.
Genomics. 1998 Jul 15;51(2):165-76. doi: 10.1006/geno.1998.5358.
The recent spreading of a subtelomeric region at nine different human chromosome ends was characterized by a combination of segregation analyses, physical mapping, junction cloning, and FISH investigations. The events occurred very recently in human genome evolution as demonstrated by sequence analysis of different alleles and the single location of the ancestral site at chromosome 17qter in chimpanzee and orangutan. The domain successfully colonized most 1p, 5q, and 6q chromosome ends and is also present at a significant frequency of 6p, 7p, 8p, 11p, 15q, and 19p ends. On 6qter, the transposed domain is immediately distal to the highly conserved, single-copy gene PDCD2.
通过分离分析、物理图谱绘制、连接克隆和荧光原位杂交（FISH）研究相结合的方法，对九个不同人类染色体末端的亚端粒区域最近的扩散情况进行了表征。如对不同等位基因的序列分析以及黑猩猩和猩猩中17qter祖先位点的单一位置所示，这些事件在人类基因组进化中发生的时间非常近。该结构域成功地定位于大多数1p、5q和6q染色体末端，并且在6p、7p、8p、11p、15q和19p末端也以相当高的频率出现。在6qter上，转座结构域紧邻高度保守的单拷贝基因PDCD2的远端。
