Kramer J A, Adams M D, Singh G B, Doggett N A, Krawetz S A
Department of Obstetrics & Gynecology, Wayne State University School of Medicine, Detroit, Michigan 48201, USA.
J Exp Zool. 1998;282(1-2):245-53.
The human male haploid expressed protamine 1 (PRM1)-->protamine 2 (PRM2)-->transition protein 2 (TNP2) locus comprises a coordinately regulated multigenic domain. This region of 16p13.13 has been used as a model to address how the organization of genes and genic domains within the human genome may influence tissue specific gene expression. Toward this goal, we have completed an extensive computational and biological analysis of the region encompassing the PRM1-->PRM2-->TNP2 domain. These analyses have revealed the likely genesis of this domain. Interestingly, the SOCS-1 gene and an hnRNPC-class pseudogene lies just 3' of this domain. Regions of nuclear matrix attachment also mark these newly identified genes.
人类男性单倍体表达的鱼精蛋白1（PRM1）→鱼精蛋白2（PRM2）→过渡蛋白2（TNP2）基因座包含一个协调调控的多基因结构域。16p13.13的这个区域已被用作一个模型，以探讨人类基因组内基因和基因结构域的组织如何影响组织特异性基因表达。为实现这一目标，我们已完成了对包含PRM1→PRM2→TNP2结构域的区域进行的广泛计算和生物学分析。这些分析揭示了该结构域可能的起源。有趣的是，细胞因子信号转导抑制因子1（SOCS-1）基因和一个不均一核糖核蛋白C类假基因位于该结构域的3'端。核基质附着区域也标记了这些新鉴定的基因。
