Platts Adrian E, Quayle Amelia K, Krawetz Stephen A
Department of Obstetrics and Gynecology, University School of Medicine, Detroit, MI 48201, USA.
Cell Mol Biol Lett. 2006;11(2):191-213. doi: 10.2478/s11658-006-0016-4.
The nuclear matrix is a functionally adaptive structural framework interior to the nuclear envelope. The nature and function of this nuclear organizer remains the subject of widespread discussion in the epigenetic literature. To draw this discussion together with a view to suggest a way forward we summarize the biochemical evidence for the modalities of DNA-matrix binding alongside the in-silico predictions. Concordance is exhibited at various, but not all levels. On the one hand, both the reiteration and sequence similarity of some elements of Matrix Attachment Regions suggest conservation. On the other hand, in-silico predictions suggest additional unique components. In bringing together biological and sequence evidence we conclude that binding may be hierarchical in nature, reflective of a biological role in replicating, transcribing and potentiating chromatin. Nuclear matrix binding may well be more complex than the widely accepted simple loop model.
核基质是核膜内部一种功能适应性结构框架。这种核组织者的性质和功能仍是表观遗传学文献中广泛讨论的主题。为了将这一讨论汇总起来并提出前进方向，我们总结了DNA与基质结合方式的生化证据以及计算机预测结果。在不同但并非所有层面都表现出一致性。一方面，基质附着区域某些元件的重复性和序列相似性表明存在保守性。另一方面，计算机预测表明存在其他独特成分。综合生物学和序列证据，我们得出结论，结合可能本质上是分层的，反映了在复制、转录和增强染色质方面的生物学作用。核基质结合可能比广泛接受的简单环模型更为复杂。
