Diebold M D, Richardson S, Duchateau A, Bigard M A, Colin R, Cortot A, Fauchère J L, Zeitoun P
Department of Pathology, Hôpital Robert Debré, Reims, France.
Dig Dis Sci. 1998 Aug;43(8):1629-35.
A cross sectional study was designed to elucidate the factors influencing the argyrophil cell population in patients with gastroesophageal reflux disease treated with omeprazole (N = 201) or H2-receptor antagonists (N = 118) and in control patients (N = 215). Fasting gastrinemia and Helicobacter pylori serology were determined. Gastritis, Helicobacter pylori infection, and argyrophil cell density and hyperplasia were evaluated in gastric biopsies. The argyrophil cell density was higher in both treatment groups than in controls (P = 0.002 and P = 0.051), whereas argyrophil cell hyperplasia was similar in the three groups. According to multivariate analysis, positive Helicobacter pylori serology was an independent parameter that decreased both density and grade of hyperplasia of argyrophil cells. Female gender and hypergastrinemia were independent factors increasing argyrophil cell density and hyperplasia, whereas antisecretory therapy, age and active gastritis were not. In addition, atrophic gastritis independently increased argyrophil cell hyperplasia. The prevalence of atrophic gastritis was significantly higher in Helicobacter pylori-positive than in negative patients and lower in the patients treated long-term with omeprazole than in the other groups.
一项横断面研究旨在阐明影响接受奥美拉唑治疗的胃食管反流病患者（N = 201）或H2受体拮抗剂治疗的患者（N = 118）以及对照患者（N = 215）中嗜银细胞群体的因素。测定空腹胃泌素血症和幽门螺杆菌血清学。在胃活检中评估胃炎、幽门螺杆菌感染以及嗜银细胞密度和增生情况。两个治疗组的嗜银细胞密度均高于对照组（P = 0.002和P = 0.051），而三组的嗜银细胞增生情况相似。根据多变量分析，幽门螺杆菌血清学阳性是一个独立参数，可降低嗜银细胞的密度和增生程度。女性性别和高胃泌素血症是增加嗜银细胞密度和增生的独立因素，而抗分泌治疗、年龄和活动性胃炎则不是。此外，萎缩性胃炎独立增加嗜银细胞增生。幽门螺杆菌阳性患者中萎缩性胃炎的患病率显著高于阴性患者，长期接受奥美拉唑治疗的患者中萎缩性胃炎的患病率低于其他组。
