Bartosch R, Granegger S, Sinzinger H
Department of Nuclear Medicine, University of Vienna, Austria.
Eur J Nucl Med. 1998 Sep;25(9):1333-5. doi: 10.1007/s002590050304.
Some groups have reported that adsorption of radiopharmaceuticals on disposable plastic syringes can reach levels of almost 50%. This high loss of radioactivity stimulated us to carry out similar studies. Our measurements were done in combination with patient studies. Therefore, we used 2-ml syringes, all of the same brand. The radioactivity in the syringe was measured immediately before and after injection. a total of 500-600 MBq technetium-99m labelled tetrofosmin or technetium-99m furifosmin was administered to 48 patients using four different injection techniques (n = 6 for each technique with each tracer): with needles, 1 min blood incubation at 22 degrees C, 10 or 30 min after preparation of the tracer; with butterflies, 1 min blood incubation at 22 degrees C, 10 or 30 min after preparation of the tracer. Neither in syringes nor in needles or butterflies did more than 7% of the initial radioactivity remain. The entire residual activity in syringe plus needle or syringe plus butterfly together never exceeded the 9% limit. Furthermore, in a pilot study we measured the remaining radioactivity in the vial; here, too, we found no more than 14% of total radioactivity. These findings indicate that total retention of radioactivity during elution and application of 99mTc-tetrofosmin and 99mTc-furifosmin with material used in our setting does not approach relevant amounts.
一些研究小组报告称，放射性药物在一次性塑料注射器上的吸附率可达近50%。这种高放射性损失促使我们开展类似研究。我们的测量是与患者研究相结合进行的。因此，我们使用的是同一品牌的2毫升注射器。在注射前后立即测量注射器中的放射性。使用四种不同的注射技术（每种示踪剂每种技术n = 6），向48名患者注射了总共500 - 600 MBq的99m锝标记替曲膦或99m锝呋膦：使用针头，在22摄氏度下血液孵育1分钟，在示踪剂制备后10或30分钟；使用蝶形针，在22摄氏度下血液孵育1分钟，在示踪剂制备后10或30分钟。注射器、针头或蝶形针中剩余的初始放射性均不超过7%。注射器加针头或注射器加蝶形针的总残留活性从未超过9%的限值。此外，在一项初步研究中，我们测量了小瓶中剩余的放射性；同样，我们发现其不超过总放射性的14%。这些发现表明，在我们的实验环境中，使用相关材料洗脱和应用99m锝 - 替曲膦和99m锝 - 呋膦期间，放射性的总保留量未达到相关数量。
