Besherdas K, Leahy A, Mason I, Harbord M, Epstein O
Centre for Gastroenterology, Department of Medicine, Royal Free Hospital School of Medicine, London, UK.
Aliment Pharmacol Ther. 1998 Aug;12(8):755-9. doi: 10.1046/j.1365-2036.1998.00369.x.
The electrogastrogram (EGG), which records gastric myoelectrical activity, is abnormal in one-third of adult patients with non-ulcer dyspepsia (NUD).
To observe the effects of cisapride on EGG in adults with NUD.
Twenty-seven NUD patients who had undergone a pre- and post-prandial EGG were entered into an open study. All patients completed a dyspepsia symptom questionnaire and were then treated with cisapride 10 mg t.d.s. The dyspepsia questionnaire was repeated in all those completing 4 weeks of treatment. Those with an initial abnormal EGG (< 70% of slow wave activity at 2-4 cycles per minute) had a repeat EGG at the end of the study.
Treatment with cisapride was associated with a significant improvement in the post-prandial EGG (P = 0.007). After 4 weeks of treatment, 7 of 13 abnormal EGGs normalized. Symptom scores improved significantly in the 13 patients with an abnormal EGG who completed treatment (P < 0.0003), but not in NUD patients with a normal EGG (P = 0.48).
In this open study, treatment of NUD with cisapride was associated with significant symptom improvement in patients with an abnormal pre-treatment EGG, but not those with a normal EGG, with a significant improvement of the post-prandial EGG.
记录胃肌电活动的胃电图（EGG）在三分之一的非溃疡性消化不良（NUD）成年患者中异常。
观察西沙必利对成年NUD患者EGG的影响。
27例接受过餐前和餐后EGG检查的NUD患者进入一项开放性研究。所有患者完成消化不良症状问卷，然后接受西沙必利10毫克每日三次治疗。所有完成4周治疗的患者重复进行消化不良问卷调查。初始EGG异常（每分钟2 - 4个周期的慢波活动<70%）的患者在研究结束时重复进行EGG检查。
西沙必利治疗与餐后EGG显著改善相关（P = 0.007）。治疗4周后，13例异常EGG中有7例恢复正常。完成治疗的13例EGG异常患者的症状评分显著改善（P < 0.0003），但EGG正常的NUD患者症状评分未改善（P = 0.48）。
在这项开放性研究中，西沙必利治疗NUD与治疗前EGG异常患者的症状显著改善相关，但EGG正常患者无此现象，且餐后EGG有显著改善。
