对干扰素诱导的转录激活的研究揭示了Jak-Stat信号通路。

Studies of IFN-induced transcriptional activation uncover the Jak-Stat pathway.

作者信息

Darnell J E

机构信息

The Rockefeller University, New York, NY 10021-6399, USA.

出版信息

J Interferon Cytokine Res. 1998 Aug;18(8):549-54. doi: 10.1089/jir.1998.18.549.

DOI:10.1089/jir.1998.18.549

PMID:9726434

Abstract

Sharing the Milstein Award with George R. Stark and Ian M. Kerr in the fall of 1997 brought this invitation to record personal reflections on our experiments concerning the mechanisms of action of interferon. Our work and that of the Kerr and Stark laboratories uncovered the Jak-Stat pathway through which signals from cell surface receptors reach genes in the cell nucleus. This review concentrates on that to which I can speak most reliably, that is, experiments done by my young colleagues at Rockefeller University.

摘要

1997年秋，与乔治·R·斯塔克和伊恩·M·克尔共同获得米尔斯坦奖后，我收到了这份邀请，要我记录下对我们关于干扰素作用机制实验的个人思考。我们的工作以及克尔和斯塔克实验室的工作揭示了Jak-Stat信号通路，通过该通路，细胞表面受体发出的信号能够抵达细胞核中的基因。这篇综述聚焦于我最有把握谈论的内容，也就是我在洛克菲勒大学的年轻同事们所做的实验。