Darnell J E
Rockefeller University, New York, New York 10021, USA.
Recent Prog Horm Res. 1996;51:391-403; discussion 403-4.
Polypeptides redirect cells by causing immediate changes in gene transcription. A direct connection between polypeptide receptors on the cell surface and genes in the nucleus has been provided by the recognition of the JAK-STAT pathway. Results leading to our present understanding of this pathway are reviewed.
多肽通过引起基因转录的即时变化来使细胞转向。JAK-STAT信号通路的发现揭示了细胞表面的多肽受体与细胞核中的基因之间的直接联系。本文综述了使我们形成目前对该信号通路理解的研究成果。
