Dalton D S, Cruickshanks K J, Klein R, Klein B E, Wiley T L
Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison 53705-2397, USA.
Diabetes Care. 1998 Sep;21(9):1540-4. doi: 10.2337/diacare.21.9.1540.
To evaluate the association of NIDDM with hearing loss in a large population-based study.
Data from population-based longitudinal studies of aging conducted in Beaver Dam, Wisconsin, were used in these analyses. Hearing thresholds were determined by pure-tone air- and bone-conduction audiometry performed by trained technicians following American Speech-Language-Hearing Association specifications. Hearing loss was defined as the pure-tone average of the frequencies 500, 1,000, 2,000, and 4,000 Hz greater than 25 decibels hearing level in the worse ear. Diabetes status was determined by self-report of physician-diagnosed diabetes or by elevated glucose or glycated hemoglobin levels at examination.
Of 3,571 study participants, 344 were classified as having NIDDM. Subjects with NIDDM were more likely to have a hearing loss than were subjects without diabetes (59 vs. 44%). After results were adjusted for age, this difference was not statistically significant. After individuals with hearing loss patterns inconsistent with presbycusis were excluded, there was an association between NIDDM and hearing loss when controlling for potential confounders (odds ratio [OR] 1.41, 95% CI 1.05-1.88). There was no association between duration of diabetes or glycemic control and hearing loss. Individuals with NIDDM and nephropathy were more likely to have a hearing loss than were those with NIDDM but no nephropathy (OR 2.28, 95% CI 1.04-5.00).
These data are suggestive of a weak association between NIDDM and hearing loss.
在一项基于大规模人群的研究中评估非胰岛素依赖型糖尿病（NIDDM）与听力损失之间的关联。
这些分析使用了在威斯康星州比弗迪尔进行的基于人群的老龄化纵向研究的数据。听力阈值由经过培训的技术人员按照美国言语 - 语言 - 听力协会的规范通过纯音气导和骨导听力测定来确定。听力损失定义为较差耳中500、1000、2000和4000赫兹频率的纯音平均值大于25分贝听力水平。糖尿病状态通过医生诊断糖尿病的自我报告或检查时血糖或糖化血红蛋白水平升高来确定。
在3571名研究参与者中，344人被归类为患有NIDDM。患有NIDDM的受试者比没有糖尿病的受试者更有可能出现听力损失（59%对44%）。在对年龄进行调整后，这种差异无统计学意义。排除听力损失模式与老年性耳聋不一致的个体后，在控制潜在混杂因素时，NIDDM与听力损失之间存在关联（优势比[OR]1.41，95%可信区间1.05 - 1.88）。糖尿病病程或血糖控制与听力损失之间没有关联。患有NIDDM和肾病的个体比患有NIDDM但无肾病的个体更有可能出现听力损失（OR 2.28，95%可信区间1.04 - 5.00）。
这些数据提示NIDDM与听力损失之间存在弱关联。
