Sakuta Hidenari, Suzuki Takashi, Yasuda Hiroko, Ito Teizo
The Department of Internal Medicine, Self-Defense Forces Central Hospital, 1-2-24 Ikejiri, Tokyo 154-8532, Japan.
Diabetes Res Clin Pract. 2007 Feb;75(2):229-34. doi: 10.1016/j.diabres.2006.06.029. Epub 2006 Sep 11.
The association of type 2 diabetes with hearing loss was evaluated in middle-aged male personnel of the Self-Defense Forces (SDFs). Hearing loss was defined as the pure-tone average (PTA) of the thresholds frequency at 0.5, 1, 2, and 4 kHz greater than 25 dB hearing levels (HL) in the worse ear. Diabetes status was determined by self-report of physician-diagnosed diabetes or by oral glucose tolerance test (OGTT). Of 699 subjects studied (age 52.9+/-1.0 years), 103 subjects were classified as having type 2 diabetes. Fasting plasma glucose of diabetic subjects was 120+/-19 mg/dl. Hearing loss levels were (worse) higher among diabetic subjects compared with subjects with normal glucose tolerance (NGT) (30.7+/-13.0 dB versus 27.4+/-12.3 dB, P=0.014). Hearing loss was more prevalent among diabetic subjects than among subjects with normal glucose tolerance (60.2% versus 45.2%, P=0.006). The odds ratio (OR) of type 2 diabetes for the presence of hearing loss was 1.87 (95% confidence interval 1.20-2.91, P=0.006) in a logistic regression analysis adjusted for age, rank, cigarette smoking and ethanol consumption. These results suggest that type 2 diabetes is associated with hearing loss independently of lifestyle factors in middle-aged men.
在日本自卫队中年男性人员中评估了2型糖尿病与听力损失之间的关联。听力损失定义为较差耳在0.5、1、2和4kHz的阈值频率的纯音平均听阈（PTA）大于25dB听力级（HL）。糖尿病状态通过医生诊断糖尿病的自我报告或口服葡萄糖耐量试验（OGTT）来确定。在699名研究对象（年龄52.9±1.0岁）中，103名被归类为患有2型糖尿病。糖尿病患者的空腹血糖为120±19mg/dl。与糖耐量正常（NGT）的受试者相比，糖尿病患者的听力损失水平（较差耳）更高（30.7±13.0dB对27.4±12.3dB，P=0.014）。糖尿病患者中听力损失比糖耐量正常的受试者更普遍（60.2%对45.2%，P=0.006）。在对年龄、军衔、吸烟和饮酒进行校正的逻辑回归分析中，听力损失存在时2型糖尿病的比值比（OR）为1.87（95%置信区间1.20-2.91，P=0.006）。这些结果表明，在中年男性中，2型糖尿病与听力损失相关，且独立于生活方式因素。
