Pajovic S B, Kasapovic J, Martinovic J
Laboratory for Molecular Biology and Endocrinology, Vinca Institute for Nuclear Sciences, Belgrade, Yugoslavia.
Physiol Res. 1997;46(5):381-4.
The activities of cytosol superoxide dismutase (CuZnSOD) and mitochondrial superoxide dismutase (MnSOD) were measured in subcellular fractions of homogenates prepared from the brain, thymus and liver of ovariectomized (OVX) female rats, non-treated or treated 24 h prior to sacrifice with a single s.c. dose of 0.1 ml olive oil. In the brain, neither MnSOD nor CuZnSOD were affected by olive oil, whereas in the thymus the olive oil injection elevated CuZnSOD and did not affect MnSOD activity. At the same time, the activity of CuZnSOD was reduced and that of MnSOD was elevated in the liver following oil treatment. These results suggest that olive oil has modulatory effects on the expression of CuZnSOD and MnSOD activity in the liver and of CuZnSOD in the thymus of female rats.
在去卵巢（OVX）雌性大鼠的脑、胸腺和肝脏匀浆的亚细胞组分中，测定了胞质超氧化物歧化酶（CuZnSOD）和线粒体超氧化物歧化酶（MnSOD）的活性。这些大鼠在处死前24小时未处理或经皮下单次注射0.1 ml橄榄油处理。在脑中，橄榄油对MnSOD和CuZnSOD均无影响，而在胸腺中，注射橄榄油可提高CuZnSOD活性，对MnSOD活性无影响。同时，经油处理后，肝脏中CuZnSOD活性降低，MnSOD活性升高。这些结果表明，橄榄油对雌性大鼠肝脏中CuZnSOD和MnSOD的表达以及胸腺中CuZnSOD的活性具有调节作用。
