Pajović S, Saicić Z S, Spasić M B, Petrović V M, Martinović J V
Laboratory for Molecular Biology and Endocrinology, Vinća Institute for Nuclear Sciences, Belgrade, Yugoslavia.
Experientia. 1996 Mar 15;52(3):221-4. doi: 10.1007/BF01920710.
The activities of mitochondrial, manganese-containing superoxide dismutase (MnSOD) and cytoplasmic, copper-zinc-containing superoxide dismutase (CuZnSOD) were measured in subcellular fractions of whole brain homogenates prepared from intact and gonadectomized (GDX) male rats, untreated or treated subcutaneously (sc) with a single dose of 2 mg progesterone (P) and/or 5 micrograms estradiol benzoate (EB). Neither MnSOD nor CuZnSOD was affected by the removal of the testes. Similarly, CuZnSOD activity was steady following systemic administration of P and/or EB to intact and GDX animals 2 h or 24 h prior to sacrifice. On the other hand, both P and EB suppressed MnSOD in the brain of either intact or GDX rats. These results suggest involvement of P and EB in the control of MnSOD activity in the brain of male rats.
在完整的和去势的（GDX）雄性大鼠制备的全脑匀浆亚细胞组分中，测定了线粒体含锰超氧化物歧化酶（MnSOD）和细胞质含铜锌超氧化物歧化酶（CuZnSOD）的活性。这些大鼠未经处理或皮下（sc）注射单剂量2mg孕酮（P）和/或5μg苯甲酸雌二醇（EB）。去除睾丸对MnSOD和CuZnSOD均无影响。同样，在处死前2小时或24小时，对完整的和去势的动物全身施用P和/或EB后，CuZnSOD活性稳定。另一方面，P和EB均抑制完整或去势大鼠脑中的MnSOD。这些结果表明P和EB参与了雄性大鼠脑中MnSOD活性的调控。
