Möller H J, Graeber M B
Psychiatric Hospital, Munich, Germany.
Eur Arch Psychiatry Clin Neurosci. 1998;248(3):111-22. doi: 10.1007/s004060050027.
In 1906, Alzheimer presented the first case of the disease which was later named Alzheimer's disease by Kraeplin. While the publication on this case in 1907 is only a relatively short communication, Alzheimer published a very comprehensive paper in 1911 in which he discussed the concept of the disease in detail. This publication focusses on the report of a second patient suffering from Alzheimer's disease, the case of Johann F. The detection of neurohistopathological sections from this patient found among archives at the Institute of Neuropathology of the University of Munich enabled us to reinvestigate this case using modern methods. Neurohistopathologically, the case of Johann F. is "plaque-only" Alzheimer's disease. There is a controversy in the modern literature as to whether these "plaque-only" cases belong to the modern concept of Alzheimer's disease. A careful analysis of all pros and contras in the literature led to the conclusion that plaque-only cases are also an integrative part of the modern Alzheimer disease concept.
1906年，阿尔茨海默报告了首例该疾病病例，后来克雷佩林将其命名为阿尔茨海默病。虽然1907年关于该病例的发表只是一篇相对简短的通讯，但阿尔茨海默在1911年发表了一篇非常全面的论文，其中他详细讨论了该疾病的概念。这篇论文重点是对第二例阿尔茨海默病患者约翰·F.病例的报告。在慕尼黑大学神经病理学研究所档案中发现的该患者神经组织病理学切片，使我们能够用现代方法重新研究这个病例。从神经组织病理学角度看，约翰·F.的病例属于“仅有斑块”型阿尔茨海默病。现代文献中对于这些“仅有斑块”的病例是否属于现代阿尔茨海默病概念存在争议。对文献中所有正反观点的仔细分析得出结论，仅有斑块的病例也是现代阿尔茨海默病概念的一个组成部分。
