不对称细胞分裂：来自果蝇和线虫的启示。

Asymmetric cell division: lessons from flies and worms.

作者信息

Lu B, Jan L Y, Jan Y N

机构信息

Howard Hughes Medical Institute, Department of Physiology, University of California, San Francisco 94143-0725, USA.

出版信息

Curr Opin Genet Dev. 1998 Aug;8(4):392-9. doi: 10.1016/s0959-437x(98)80108-1.

DOI:10.1016/s0959-437x(98)80108-1

PMID:9729713

Abstract

Insights into the mechanisms of asymmetric cell division have recently been obtained from studies in genetically amenable systems such as Drosophila and Caenorhabditis elegans. These studies have emphasized the importance of cortically localized polarity organizing molecules, adapter molecules, and the actin cytoskeleton in controlling unequal segregation of cell-fate determinants and spindle orientation. The control of asymmetric cell divisions by Wnt signaling in C. elegans and Frizzled signaling in Drosophila reveals additional mechanisms for modulating cellular polarity and suggests that there are some similarities between the two systems.

摘要

最近，通过对果蝇和秀丽隐杆线虫等易于进行基因研究的系统开展研究，人们对不对称细胞分裂机制有了深入了解。这些研究强调了皮质定位极性组织分子、衔接分子和肌动蛋白细胞骨架在控制细胞命运决定因子的不均等分离和纺锤体定向方面的重要性。秀丽隐杆线虫中Wnt信号通路以及果蝇中卷曲蛋白信号通路对不对称细胞分裂的控制揭示了调节细胞极性的其他机制，并表明这两个系统之间存在一些相似之处。