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鹦鹉热衣原体的细胞内生存:细菌如何与宿主细胞相互作用?

The intracellular life of Chlamydia psittaci: how do the bacteria interact with the host cell?

作者信息

Escalante-Ochoa C, Ducatelle R, Haesebrouck F

机构信息

Department of Pathology, Bacteriology and Avian Diseases, Faculty of Veterinary Medicine, University of Ghent, Belgium.

出版信息

FEMS Microbiol Rev. 1998 Jun;22(2):65-78. doi: 10.1111/j.1574-6976.1998.tb00361.x.

Abstract

Throughout the life of any organism interactions with the surrounding environment are always taking place, a process that leads to evolution. Chlamydia psittaci is an obligate intracellular parasite, but it must also be capable of extracellular survival in order to search for new host cells. Therefore, these peculiar prokaryotes have evolved two different particles and a unique developmental cycle that, together with a series of not yet fully understood interactions with their host cells, allow them to fulfil the requirements for their permanence in nature. These interactions are the subject of this paper. Particular attention is paid to the attachment and internalization of the bacteria, the chlamydial vacuole, and the avoidance of lysosomal degradation.

摘要

在任何生物体的整个生命过程中,与周围环境的相互作用一直在发生,这一过程导致了进化。鹦鹉热衣原体是一种专性细胞内寄生虫,但它也必须能够在细胞外存活,以便寻找新的宿主细胞。因此,这些特殊的原核生物进化出了两种不同的颗粒和独特的发育周期,再加上一系列与宿主细胞尚未完全了解的相互作用,使它们能够满足在自然界中存续的要求。这些相互作用是本文的主题。本文特别关注细菌的附着和内化、衣原体空泡以及避免溶酶体降解。

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