Donaghue V M, Chrzan J S, Rosenblum B I, Giurini J M, Habershaw G M, Veves A
Beth Israel Deaconsess Medical Center, Harvard Medical School, Boston, MA, USA.
Adv Wound Care. 1998 May-Jun;11(3):114-9.
Efficacy and safety of a collagen-alginate topical wound dressing (FIBRACOL Collagen-Alginate Wound Dressing) in the treatment of diabetic foot ulcers was compared with that of regular gauze moistened with normal saline. Seventy-five patients with foot ulcers were assigned randomly in a 2:1 ratio to the collagen-alginate test dressing or the gauze dressing. At the end of the study, the mean percent reduction of the wound area was 80.6% +/- 6% in the collagen-alginate dressing group and 61.1% +/- 26% in the gauze dressing group (p = .4692). Thirty-nine (78%) patients treated with the collagen-alginate dressing achieved > or = 75% wound area reduction, compared with 15 (60%) of gauze-treated patients. Complete healing was achieved in 24 (48%) of the collagen-alginate dressing group and 9 (36%) of the gauze dressing group. Wound size, when averaged over the 8-week period and with the duration of the ulcer taken into account, was reduced significantly in the collagen-alginate dressing group, as compared with the gauze dressing group (df = 1, p = .0049). It is concluded that the collagen-alginate test dressing is as or more effective and safe as the currently used treatment.
将一种胶原蛋白-藻酸盐局部伤口敷料（FIBRACOL胶原蛋白-藻酸盐伤口敷料）用于治疗糖尿病足溃疡的疗效和安全性与用生理盐水浸湿的普通纱布进行了比较。75例足部溃疡患者按2:1的比例随机分配至胶原蛋白-藻酸盐试验敷料组或纱布敷料组。研究结束时，胶原蛋白-藻酸盐敷料组伤口面积平均减少百分比为80.6%±6%，纱布敷料组为61.1%±26%（p = 0.4692）。使用胶原蛋白-藻酸盐敷料治疗的39例（78%）患者伤口面积减少≥75%，而使用纱布治疗的患者为15例（60%）。胶原蛋白-藻酸盐敷料组24例（48%）实现完全愈合，纱布敷料组9例（36%）实现完全愈合。与纱布敷料组相比，考虑到溃疡持续时间，在8周期间平均计算的伤口大小在胶原蛋白-藻酸盐敷料组中显著减小（自由度=1，p = 0.0049）。得出的结论是，胶原蛋白-藻酸盐试验敷料与目前使用的治疗方法一样有效或更有效且更安全。
