Vogel T, Dittrich O, Mehraein Y, Dechend F, Schnieders F, Schmidtke J
Institut für Humangenetik, Medizinische Hochschule Hannover, Hannover, Germany.
Cytogenet Cell Genet. 1998;81(3-4):265-70. doi: 10.1159/000015042.
Using expressed sequence tag (EST) sequence information, novel genes related to the Y chromosome gene family TSPY were isolated and characterized. Because of a significant homology to TSPY, the novel genes were designated TSPY-Like (TSPYL) and were assigned as new members of the TSPY-SET-NAP1L1 family. A human TSPYL gene was localized on chromosome 6 and a murine Tspyl gene was localized on chromosome 10. Expression of TSPYL was observed in all tissues investigated, as well as early onset during development. Both the human and murine Tspyl homologs lack introns over the entire region so far investigated and are thought to have arisen by an ancient retroposition event. Retroposition of Tspyl genes is supported by the isolation of a murine Tspyl pseudogene on chromosome 12 which also lacks intronic sequences, and by its observed proximity to an R element, a family of dispersed repetitive DNA.
利用表达序列标签（EST）序列信息，分离并鉴定了与Y染色体基因家族TSPY相关的新基因。由于与TSPY具有显著同源性，这些新基因被命名为类TSPY（TSPYL），并被指定为TSPY-SET-NAP1L1家族的新成员。人类TSPYL基因定位于6号染色体，小鼠Tspyl基因定位于10号染色体。在所有研究的组织中均观察到TSPYL的表达，并且在发育早期就开始表达。到目前为止，人类和小鼠的Tspyl同源物在整个研究区域都没有内含子，被认为是由一个古老的逆转座事件产生的。在12号染色体上分离出一个也缺乏内含子序列的小鼠Tspyl假基因，以及观察到它与R元件（一种分散的重复DNA家族）的接近程度，都支持了Tspyl基因的逆转座。
