一种鼠源TSPY。
A murine TSPY.
作者信息
Vogel T, Boettger-Tong H, Nanda I, Dechend F, Agulnik A I, Bishop C E, Schmid M, Schmidtke J
机构信息
Institute of Human Genetics, Medizinische Hochschule Hannover, Germany.
出版信息
Chromosome Res. 1998 Jan;6(1):35-40. doi: 10.1023/a:1009214307764.
Sequences homologous to human and bovine TSPY were isolated from M. musculus testicular cDNA, and a nearly full-length gene was polymerase chain reaction (PCR) amplified from mouse genomic DNA. This gene is apparently non-functional. Contrary to the situation encountered in species along the primate and artiodactyl lineages, in which TSPY is moderately repetitive, murine Tspy appears to be single copy. Murine Tspy is located on Yp, i.e. in the same syntenic group as in man. Sequence comparisons of murine, human and bovine TSPY exons suggest that TSPY became non-functional during rodent evolution.
从小家鼠睾丸cDNA中分离出与人类和牛TSPY同源的序列，并通过聚合酶链反应（PCR）从小鼠基因组DNA中扩增出一个几乎全长的基因。该基因显然无功能。与灵长类和偶蹄目动物谱系中遇到的情况相反，在这些物种中TSPY具有中度重复性，而小鼠的Tspy似乎是单拷贝的。小鼠Tspy位于Yp上，即与人类位于同一条同线群中。小鼠、人类和牛TSPY外显子的序列比较表明，TSPY在啮齿动物进化过程中失去了功能。
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