Sundgren-Andersson A K, Ostlund P, Bartfai T
Department of Neurochemistry and Neurotoxicology, Arrhenius Laboratories for Natural Sciences, Stockholm University, Stockholm, Sweden.
Neuroimmunomodulation. 1998 Sep-Oct;5(5):241-7. doi: 10.1159/000026344.
The neuropathological outcome of metabolic, vascular or mechanical insults to the CNS depends on brain temperature; mild hypothermia is neuroprotective, whereas elevated brain temperature can cause additional neural damage. Studies in both animals and humans have shown that the core and the brain temperature do not always concur with one another. It is therefore important to develop methods for monitoring brain temperature. This paper describes an animal model (the rat) in which we have developed a method to measure, at thermoneutral ambient temperature, the brain and core temperature concomitantly, during different drug treatments. We have used this animal model to study body temperature during fever (induced by human recombinant IL-1 beta, 5 microgram/kg, i.p.), stress-induced hyperthermia (handling of the animal), hypothermia (induced by (+/-)-8-hydroxy-2-dipropylaminotetralin hydrobromide, 0.5 mg/kg, i.p. ) and sleep (non-induced, other than by light and diurnal variation). We show that the thermal curves are similar in the brain and the peritoneum, independent of the thermal state.
中枢神经系统遭受代谢、血管或机械性损伤后的神经病理学结果取决于脑温；轻度低温具有神经保护作用，而脑温升高则会导致额外的神经损伤。对动物和人类的研究均表明，核心体温与脑温并不总是一致。因此，开发监测脑温的方法很重要。本文描述了一种动物模型（大鼠），我们在其中开发了一种方法，可在热中性环境温度下，在不同药物治疗期间同时测量脑温和核心体温。我们已使用该动物模型研究发热（由重组人白细胞介素-1β，5微克/千克，腹腔注射诱导）、应激性体温过高（动物处理）、低温（由（±）-8-羟基-2-二丙基氨基四氢萘氢溴酸盐，0.5毫克/千克，腹腔注射诱导）和睡眠（非诱导，除了光照和昼夜变化）期间的体温。我们发现，无论热状态如何，脑和腹膜的热曲线相似。
