Gallaher E J, Egner D A
Psychopharmacology (Berl). 1987;91(1):34-9. doi: 10.1007/BF00690923.
We have recently described a telemetry/microcomputer system to monitor core temperatures in rats. We implant a miniature transmitter (Mini-mitter) into the peritoneal cavity of the rat, allowing us to obtain temperatures around the clock without handling the animals or disturbing the light-dark cycle. In the present study we describe the temperature effects of ethanol doses ranging from 2 to 6 g/kg. Baseline temperatures were collected for 2 days before drug was administered. Subsequent computer analysis then allowed us to compare experimental results in each animal with its own baseline temperature to allow for individual and circadian temperature differences. In preliminary studies we observed the well-known dose-dependent hypothermic effect of ethanol. However, by observing animals continually over 4 days we also observed a period of rebound hyperthermia beginning at about the time of complete ethanol elimination and persisting for several days. During this period daytime temperatures remained at the normally high night-time level. This may be evidence of a mild abstinence syndrome, or alternatively, may be due to a disruption of the normal circadian temperature rhythm.
我们最近描述了一种用于监测大鼠核心体温的遥测/微型计算机系统。我们将一个微型发射器（Mini-mitter）植入大鼠的腹腔，这样我们就可以在不接触动物或不干扰昼夜节律的情况下全天候获取体温。在本研究中，我们描述了2至6克/千克乙醇剂量的温度效应。在给药前2天收集基线体温。随后的计算机分析使我们能够将每只动物的实验结果与其自身的基线体温进行比较，以考虑个体和昼夜体温差异。在初步研究中，我们观察到了乙醇众所周知的剂量依赖性体温过低效应。然而，通过连续4天观察动物，我们还观察到大约在乙醇完全消除时开始并持续数天的体温反弹性高热期。在此期间，白天的体温保持在正常的夜间高水平。这可能是轻度戒酒综合征的证据，或者，也可能是由于正常昼夜体温节律的紊乱。
