Damian E
Endocrinologie. 1976 Jul-Sep;14(3):185-91.
The study presents the data gathered along the years on the antisteroid action of the pineal gland. Thus, it was demonstrated that administration of pineal polypeptides to the rabbit lowers the urinary 17-KS both of testicular and adrenal origin. Conversely, pinealectomy caused an increase in the level of these steroid hormones. The same pineal material induced a marked decrease both in the serum and testicular testosterone and in the plasma and adrenal corticosterone in the rat. At the same time administration of pineal polypeptides lowered the cholesterol in the serum, bile, liver, testis and adrenal. Melatonin had no effect on these biochemical indices, which demonstrates that the effects obtained with pineal polypeptides are not mediated by melatonin.
该研究展示了多年来收集的关于松果体抗类固醇作用的数据。因此，已证明给兔子注射松果体多肽会降低睾丸和肾上腺来源的尿17-酮类固醇。相反，松果体切除导致这些类固醇激素水平升高。相同的松果体物质使大鼠血清和睾丸中的睾酮以及血浆和肾上腺中的皮质酮显著降低。同时，注射松果体多肽可降低血清、胆汁、肝脏、睾丸和肾上腺中的胆固醇。褪黑素对这些生化指标没有影响，这表明松果体多肽所产生的作用不是由褪黑素介导的。
