Goel H C, Prasad J, Sharma A, Singh B
Department of Radiation Biology, Institute of Nuclear Medicine & Allied Sciences, Delhi, India.
Indian J Exp Biol. 1998 Jun;36(6):583-7.
A significant antitumour effect of P. hexandrum, a herb thriving at Himalayas (2500-4000 m), was observed in strain 'A' mice carrying solid tumours developed by transplanting Ehrlich ascites tumour (EAT). Subtoxic well tolerated sequential doses of aqueous extract of P. hexandrum (a daily dose of 34.5 mg/kg b.w. for 15 days) enhanced tumour doubling time (TDT) from 1.94 +/- 0.26 days to 19.1 +/- 2.5 days. However, no synergism was revealed between radiation and P. hexandrum, though both independently manifested antitumour effects. In normal mice, pre-irradiation administration of extract of P. hexandrum protected mice in a dose dependent manner (optimal dose being 34.5 mg/kg body.wt. rendering 72% survival for 30 days) against whole body lethal irradiation of 10 Gy. Radioprotective properties of P. hexandrum were found to be comparable to synthetic radioprotectors like diltiazem etc.
在携带通过移植艾氏腹水瘤（EAT）形成的实体瘤的“A”品系小鼠中，观察到生长于喜马拉雅山脉（海拔2500 - 4000米）的草药匙叶翼首草具有显著的抗肿瘤作用。匙叶翼首草水提取物的亚毒性且耐受性良好的序贯剂量（每日剂量34.5毫克/千克体重，共15天）使肿瘤倍增时间（TDT）从1.94±0.26天延长至19.1±2.5天。然而，尽管辐射和匙叶翼首草各自都表现出抗肿瘤作用，但二者之间未显示出协同作用。在正常小鼠中，预先给予匙叶翼首草提取物进行辐射防护，呈现出剂量依赖性（最佳剂量为34.5毫克/千克体重，可使72%的小鼠存活30天），可抵御10戈瑞的全身致死性辐射。发现匙叶翼首草的辐射防护特性与地尔硫䓬等合成辐射防护剂相当。
