Walker G A, Walker D W, Lithgow G J
The School of Biological Sciences, The University of Manchester, UK.
J Investig Dermatol Symp Proc. 1998 Aug;3(1):6-10.
Studies of aging in the nematode Caenorhabditis elegans have revealed a relationship between stress resistance and the rate of aging: Mutations which extend mean and maximum life-span also confer resistance to thermal stress. We review the molecular genetics of aging in C. elegans and introduce methods for obtaining novel mutants which display altered aging rates. We present the use of the "surrogate" phenotype of thermotolerance to develop a selection for novel mutations which slow aging.
延长平均寿命和最大寿命的突变也赋予了对热应激的抗性。我们综述了秀丽隐杆线虫衰老的分子遗传学，并介绍了获得显示衰老速率改变的新型突变体的方法。我们展示了利用耐热性的“替代”表型来筛选延缓衰老的新型突变。
