Horiguchi Y, Lee S G, Matsumoto I, Arima N, Fujii H, Ohnuma Y, Imamura S
Department of Dermatology, Osaka Red Cross Hospital, Osaka, Japan.
Dermatology. 1998;197(2):174-7. doi: 10.1159/000017993.
The development of different types of neutrophilic dermatosis is reported to occur in the course of malignant hemopathies. These concern mainly Sweet's syndrome, pyoderma gangrenosum, erythema elevatum et diutinum and neutrophilic eccrine hidradenitis.
We have recently encountered the cases of 3 patients who presented all with multiple acneiform papules and dome-shaped aseptic abscesses leaving scars. Pus was sterile in all except case 3 in which slight Staphylococcus aureus growth was shown. However, in this patient, only steroids were effective demonstrating that this bacterium was not responsible for the disease. Histopathology disclosed a dense dermal polymorphonuclear neutrophil infiltrate and some mononuclear cells. Two of these patients had myelodysplastic syndromes while one had IgA myeloma.
Abscess-forming neutrophilic dermatosis seems to be another type of neutrophilic dermatosis associated with hematological malignancies.
据报道，不同类型的嗜中性皮病在恶性血液病病程中发生。这些主要涉及Sweet综合征、坏疽性脓皮病、持久性隆起性红斑和嗜中性小汗腺炎。
我们最近遇到3例患者，他们均表现为多发性痤疮样丘疹和留下瘢痕的圆顶形无菌脓肿。除病例3显示有轻微金黄色葡萄球菌生长外，其他所有病例的脓液均无菌。然而，在该患者中，仅类固醇有效，表明该细菌与疾病无关。组织病理学显示真皮有密集的多形核中性粒细胞浸润和一些单核细胞。其中2例患者患有骨髓增生异常综合征，1例患有IgA骨髓瘤。
形成脓肿的嗜中性皮病似乎是另一种与血液系统恶性肿瘤相关的嗜中性皮病。
