McAllister M F, Evans D G, Ormiston W, Daly P
Centre for Family Research, Faculty of Social and Political Sciences, University of Cambridge, UK.
J Med Genet. 1998 Sep;35(9):739-44. doi: 10.1136/jmg.35.9.739.
In inherited forms of breast cancer, attention in clinical genetics services has focused on women because they are most at risk of developing cancer. Men at risk of transmitting a predisposing gene mutation are less likely to have a genetic test than the women in these families. This preliminary study investigates the perspective of the brothers of women with familial breast cancer and is based on qualitative analysis of 22 semistructured interviews using an attenuated form of Grounded Theory. There is an awareness among these men (without having had genetic counselling) that the breast cancer in their families is inherited. Some of them harbour fear of developing cancer themselves and many are concerned that their daughters might develop breast cancer. Some appeared to use avoidance as a coping strategy. The men were very often excluded from family conversations about breast cancer. Implications for the provision of genetic counselling for these families are discussed.
在遗传性乳腺癌中，临床遗传学服务的关注点集中在女性身上，因为她们患癌风险最高。与这些家族中的女性相比，有传递易感基因突变风险的男性进行基因检测的可能性较小。这项初步研究调查了患有家族性乳腺癌女性的兄弟的观点，该研究基于对22次半结构化访谈的定性分析，采用了一种简化形式的扎根理论。这些男性（未接受过遗传咨询）意识到他们家族中的乳腺癌是遗传性的。他们中的一些人担心自己会患癌，许多人担心自己的女儿可能会患乳腺癌。一些人似乎将回避作为应对策略。这些男性经常被排除在关于乳腺癌的家庭讨论之外。文中讨论了为这些家庭提供遗传咨询的意义。
