Wiig K A, Burwell R D
Department of Neuroscience, Brown University, Providence, Rhode Island 02912, USA.
Behav Neurosci. 1998 Aug;112(4):827-38. doi: 10.1037//0735-7044.112.4.827.
Previous research conducted in monkeys and rats has established that the perirhinal cortex is critically involved in object- or stimulus-recognition memory, whereas other research suggests this region may contribute to memory for object discriminations. These findings do not rule out the possibility that the perirhinal cortex plays a more general role in memory. The present experiment addressed whether selective lesions of the perirhinal cortex would result in a delay-dependent deficit on a test of memory that did not involve stimulus recognition or object memory. Rats with bilateral perirhinal lesions were tested on a delayed non-matching-to-position task. Lesions of the perirhinal cortex did not interfere with acquisition or performance at short (0-4 s)-delay intervals, but lesions did impair performance at longer delays. It is suggested that the perirhinal cortex is involved in maintaining representations of trial-specific information over time.
先前在猴子和大鼠身上进行的研究已证实，嗅周皮质在物体或刺激识别记忆中起着关键作用，而其他研究表明该区域可能有助于物体辨别记忆。这些发现并未排除嗅周皮质在记忆中发挥更广泛作用的可能性。本实验探讨了嗅周皮质的选择性损伤是否会在一项不涉及刺激识别或物体记忆的记忆测试中导致延迟依赖性缺陷。对双侧嗅周皮质损伤的大鼠进行了延迟位置非匹配任务测试。嗅周皮质损伤在短延迟（0 - 4秒）间隔时并不干扰习得或表现，但在较长延迟时会损害表现。研究表明，嗅周皮质参与随着时间维持特定试验信息的表征。
