Liu P, Bilkey D K
Department of Psychology and Neuroscience Research Centre, University of Otago, Dunedin, New Zealand.
Behav Neurosci. 1998 Jun;112(3):512-24. doi: 10.1037//0735-7044.112.3.512.
Rats with bilateral electrolytic or ibotenic acid lesions that were centred in perirhinal cortex displayed a significant delay-dependent deficit on a delayed nonmatch to position task in the T maze. Although the removal of prominent extramaze visual cues did not affect the performance of these rats, rotating the maze between the sample and test phases did, indicating that rats were using a spatial strategy. Interestingly, a further group of rats with hippocampal and perirhinal damage displayed deficits that may reflect a dysfunction in the use of inertial cues. These results suggest that both electrolytic and excitotoxic lesions of perirhinal cortex produce spatial memory impairments but that these impairments are qualitatively different than those exhibited following hippocampal damage.
双侧电解损伤或注射鹅膏蕈氨酸损伤以鼻周皮质为中心的大鼠，在T迷宫的延迟位置匹配任务中表现出显著的延迟依赖性缺陷。尽管去除突出的迷宫外部视觉线索并不影响这些大鼠的表现，但在样本阶段和测试阶段之间旋转迷宫则会影响其表现，这表明大鼠使用的是空间策略。有趣的是，另一组海马体和鼻周皮质受损的大鼠表现出的缺陷可能反映了惯性线索使用功能障碍。这些结果表明，鼻周皮质的电解损伤和兴奋性毒性损伤都会导致空间记忆受损，但这些损伤在性质上与海马体损伤后表现出的损伤不同。
