Ljungman P, Halasz R, Hägglund H, Sönnerborg A, Ringdén O
Department of Hematology, Huddinge University Hospital, Karolinska Institutet, Sweden.
Bone Marrow Transplant. 1998 Sep;22(5):499-501. doi: 10.1038/sj.bmt.1701366.
Abnormal liver function before allogeneic BMT has been associated with VOD. Hepatitis G virus/GB virus C (HGV) is a recently discovered virus suggested to be a cause of non-A, non-B, non-C, non-D and non-E hepatitis. The aim of this retrospective study was to analyze the risk for liver complications and time to engraftment in patients infected with HGV. Fifty patients transplanted in 1995 were examined with RT-PCR for HGV on samples collected before, and between 3 and 6 months after BMT. Seven patients had HGV detected before BMT. No patient became infected during or early after the BMT. There were no differences in either pre- or post-transplant liver function abnormalities, VOD, or time to neutrophil engraftment in patients who did or did not have HGV detected before BMT. We conclude that the importance of HGV infection for the development of post-transplant complications is limited.
异基因骨髓移植前肝功能异常与肝静脉闭塞病（VOD）有关。庚型肝炎病毒/GB病毒C型（HGV）是一种最近发现的病毒，被认为是非甲、非乙、非丙、非丁和非戊型肝炎的病因。这项回顾性研究的目的是分析感染HGV的患者发生肝脏并发症的风险以及植入时间。对1995年接受移植的50例患者在骨髓移植前以及移植后3至6个月期间采集的样本进行了HGV的逆转录聚合酶链反应（RT-PCR）检测。7例患者在骨髓移植前检测到HGV。没有患者在骨髓移植期间或移植后早期感染。在骨髓移植前检测到或未检测到HGV的患者中，移植前或移植后肝功能异常、VOD或中性粒细胞植入时间均无差异。我们得出结论，HGV感染对移植后并发症发生的重要性有限。
